Every year, the Swiss Foundation for Tuberculosis Research awards the Swiss TB Award for outstanding work by Swiss researchers.
The two winners this year are Nina T. Odermatt from the EPFL Lausanne and Tobias Broger from the Swiss non-profit organisation FIND.
Tobias Broger MSc FIND, Genfeva Switzerland
New generation urine test improves TB diagnosis in people living with HIV
The Fujifilm SILVAMP TB LAM test, or FujiLAM, is the first of a new generation of rapid diagnostic tests for the identification of TB in people co-infected with HIV. Working in a similar way to a pregnancy test, FujiLAM detects low concentrations of lipoarabinomannan (LAM) in the urine of people with TB and HIV co-infection. Urine samples are easy to collect from people of all ages, which is especially relevant for those with HIV who may often face difficulties in producing sputum (the usual sample needed for TB tests). FujiLAM has shown promise following an encouraging diagnostic accuracy evaluation using biobanked (frozen) urine samples from hospitalized patients with HIV, and these findings were presented in a study published in the journal Lancet Infectious Diseases. The study found that the test is substantially (28%) more effective at identifying TB in people who are HIV positive than the only existing alternative urine test. Rapid and accurate diagnosis of TB is critical to enable patients to start treatment on time, reduce deaths due to TB, and prevent further transmission of the disease. The test is now being evaluated in large studies in more than ten countries, which will help to generate the data needed for evaluation by the World Health Organization (WHO).
SILVAMP TB LAM was developed by a FIND-led international R&D consortium including Fujifilm, Rutgers University, the University of Alberta, Otsuka and the University of Cape Town, supported by the Global Health Innovation Technology Fund (GHIT), the Bill & Melinda Gates Foundation, and the governments of Germany, the Netherlands, UK and Australia.
Broger T, Sossen B, du Toit E, Kerkhoff AD, Schutz C, Ivanova Reipold E, Ward A, Barr DA, Macé A, Trollip A, Burton R, Ongarello S, Pinter A, Lowary TL, Boehme C, Nicol MP, Meintjes G, Denkinger CM. Novel lipoarabinomannan point-of-care tuberculosis test for people with HIV: a diagnostic accuracy study. Lancet Infect Dis 2019;19:852–861. doi:10.1016/S1473-3099(19)30001-5.
Broger T, Sossen B, du Toit E, Kerkhoff AD, Schutz C, Ivanova Reipold E, Ward A, Barr DA, Macé A, Trollip A, Burton R, Ongarello S, Pinter A, Lowary TL, Boehme C, Nicol MP, Meintjes G, Denkinger CM. Novel lipoarabinomannan point-of-care tuberculosis test for people with HIV: a diagnostic accuracy study. Lancet Infect Dis. 2019;19: 852–861. doi:10.1016/S1473-3099(19)30001-5